The lecture is prompted by the paper of Prof. Roald Hoffmann (The Journal of Aesthetics Art Criticism, 48, 191-204, 1990) beadwk of my colleague, Prof. Bih-Yaw Jin. The intention of the lecture is to introduce the structural chemistry to general audiences. Many beautiful molecules are presented by drawing, picture real 3D model instead of difficult chemist’s language. After simple introduction of chemical bond, many molecules are showing from ganic molecules to inganic molecules, codination complexes ganometallic complexes. Then giant molecules, proteins, DNAs even virus will be illustrated. The final remark will be focused on my research molecules: metal string complexes. These molecules are fundamentally imptant in the study of metal-metal bonding also have great potential applications as molecular electronics.